Jeff Robinson scored 17 points, and Travis Taylor added 15 points and nine rebounds to help Xavier beat cold-shooting Butler 62-47 on Tuesday.
Justin Martin added 10 points for Xavier (2-0), and Dee Davis led a defensive effort that limited Butler (1-1) to 36.5 shooting percentage (19 of 52), including 25 percent (7 of 28) in the second half.
Davis scored nine points while helping hold Butler guard Rotnei Clarke to seven points after he scored 21 in Butler's season-opening 74-59 victory over Elon on Saturday.
Xavier shot 50 percent (23 of 46), never trailed and led by 20 points late in the game.
Freshman Kellen Dunham led Butler with 11 points. Andrew Smith added nine points, all in 15 minutes of the first half after going scoreless in Butler's opener.
Playing before a crowd of 9,876 that showed up at the 10,250-seat Cintas Center for the rare late-afternoon weekday game, Xavier improved its overall record against Butler to 31-16. The Musketeers have won 10 of the last 12 games against the Bulldogs, including the last three.
Even though both teams are in the Atlantic 10, the game was not a conference matchup, because it was scheduled before Butler joined the A-10 this season. The teams are scheduled to meet in their regular-season finale March 9 in what will count as a conference game.
Robinson, who scored 16 points in Xavier's 117-75 season-opening victory over Fairleigh Dickinson on Friday, had 12 points in the first half as the Musketeers built a 32-18 lead before settling for a 36-29 halftime advantage. The Bulldogs made just one of their first 10 shots in the second half, allowing the Musketeers to open a 46-33 lead.